Evolution of hospital discharge rates due to middle ear cholesteatoma in the period 2020 to 2023 in Chile
DOI:
https://doi.org/10.52611/confluencia.2026.1733Keywords:
Cholesteatoma, Middle ear, Otolaryngology, Epidemiology, Chile, HospitalizationAbstract
Introduction: Bronchus middle ear cholesteatoma is an invasive cystic lesion characterized by the accumulation of desquamated keratin and debris. In Chile the epidemiology of this condition remains unclear. Objective: To calculate the hospital discharge rate for middle ear cholesteatoma during the period 2020-2023 in Chile. Methodology: An observational, descriptive, longitudinal and retrospective study was conducted on the hospital discharge rate for middle ear cholesteatoma in the total population, according to sex, age, and length of hospital stay. Scientific ethics committee approval was not required. Result: A total of 1.359 cases were analyzed, determining an hospital discharge rate of 1,93 cases per 100.000 inhabitants during the study period, with an increasing trend over the years studied. A predominance in young males up to 19 years of age was observed, whereas from 45 years onward, females predominated. The mean length of hospital stay was 1,82 days. Discussion: The increase in hospital discharge rate may be attributed to the impact of the SARS-CoV-2 pandemic and the redistribution of healthcare resources. This may also have influenced the differences in rates between sexes. The predominance of young males and older females may be explained by the higher incidence of congenital cholesteatoma and Eustachian tube dysfunction, respectively. Finally, the longer hospital stay in older individuals may be explained by the higher prevalence of comorbidities. Conclusion: A trend similar to that observed in other countries is presented, suggesting that anatomical and physiological factors influence the disease. Further studies are required to establish appropriate management strategies.
References
1. Wilson E, Jennings BA, Khondoker M, Philpott CM, Prinsley P, Brewer DS. Epidemiology of Cholesteatoma in the UK Biobank. Clin Otolaryngol [Internet]. 2025 [citado el 22 de marzo 2026];50(2):316-29. Disponible en: https://doi.org/10.1111/coa.14257
2. Navarro D, Opazo C, Maturana J, Mucientes F, Sepúlveda I, Schmidt T. Colesteatoma congénito: caso clínico y revisión de literatura. Rev Otorrinolaringol Cir Cabeza Cuello [Internet]. 2023 [citado el 22 de marzo 2026];83(1):30-6. Disponible en: https://doi.org/10.4067/s0718-48162023000100030
3. Xing B, Dang Y, Xi K. Cholesteatoma: An Updated Review of Molecular Pathogenesis and Potential Therapeutic Directions. Curr Med Chem [Internet]. 2026 [citado el 30 de agosto 2026];33(3):616-29. Disponible en: https://doi.org/10.2174/0109298673404489250515074316
4. Lujic S, Randall DA, Simpson JM, Falster MO, Jorm LR. Interaction effects of multimorbidity and frailty on adverse health outcomes in elderly hospitalised patients. Sci Rep [Internet]. 2022 [citado el 22 de marzo 2026];12(1):14139. Disponible en: https://doi.org/10.1038/s41598-022-18346-x
5. Xu JY, Madden HE, Martínez-Camblor P, Deiner SG. Frailty as an independent risk factor for prolonged postoperative length of stay: A retrospective analysis of 2015–2019 ACS NSQIP data. J Clin Anesth [Internet]. 2025 [citado el 22 de marzo 2026];101:111730. Disponible en: https://doi.org/10.1016/j.jclinane.2024.111730
6. Gilberto N, Custódio S, Colaço T, Santos R, Sousa P, Escada P. Middle ear congenital cholesteatoma: systematic review, meta-analysis and insights on its pathogenesis. Eur Arch Otorhinolaryngol [Internet]. 2020 [citado el 22 de marzo 2026];277(4):987-98. Disponible en: https://doi.org/10.1007/s00405-020-05792-4
7. Kennedy KL, Singh AK. Middle ear cholesteatoma. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 [citado el 22 de marzo 2026]. Disponible en: https://www.ncbi.nlm.nih.gov/books/NBK448108/
8. Rosito LP, da Silva MN, Selaimen FA, Jung YP, Pauletti MG, Jung LP, et al. Characteristics of 419 patients with acquired middle ear cholesteatoma. Braz J Otorhinolaryngol [Internet]. 2017 [citado el 22 de marzo 2026];83(2):126-31. Disponible en: https://doi.org/10.1016/j.bjorl.2016.02.013
9. Alshamani MR, Alandijani HA, Alhussaini OM, Alharbi RA, Almeshaly SS, Alraddadi AF, et al. Prevalence of Eustachian Tube Dysfunction and Its Associated Factors Among the General Public in Al-Madinah, Saudi Arabia. Cureus [Internet]. 2023 [citado el 22 de marzo 2026];15(1):e33735. Disponible en: https://doi.org/10.7759/cureus.33748
10. Janzen-Senn I, Schuon RA, Tavassol F, Lenarz T, Paasche G. Dimensions and position of the Eustachian tube in Humans. PLoS ONE [Internet]. 2020 [citado el 16 de octubre 2024];15(5):e0232655. Disponible en: https://doi.org/10.1371/journal.pone.0232655
11. Fandiño Cárdenas M, Delgado Caballero SP, Camelo Pardo G, Pinzón Vargas S, Bueno Prato NKJ. Abordaje y decisiones en el colesteatoma: revisión de la literatura. Rev Salud UDH [Internet]. 2023 [citado el 22 de marzo 2026];5(1):38-41. Disponible en: https://doi.org/10.37711/rpcs.2023.5.1.400
12. Xun M, Liu X, Sha Y, Zhang X, Liu JP. The diagnostic utility of diffusion-weighted magnetic resonance imaging and high-resolution computed tomography for cholesteatoma: A meta-analysis. Laryngoscope Investig Otolaryngol [Internet]. 2023 [citado el 30 de agosto 2026];8(3):627-35. Disponible en: https://doi.org/10.1002/lio2.1032
13. Swain SK. Current practices of canal wall up versus canal wall down mastoidectomy: a review. Int J Res Med Sci [Internet]. 2024 [citado el 30 de agosto 2026];12(8):3117-23. Disponible en: https://doi.org/10.18203/2320-6012.ijrms20242254
14. Melariri H, Balakrishna Y, Mukhtar A, Joseph E, Labuschagne S, Hapunda-Chibanga R, et al. The Global Burden of Cholesteatoma: A Systematic Review and Meta-analysis. Otolaryngol Head Neck Surg [Internet]. 2026 [citado el 30 de agosto 2026];174(1):45-56. Disponible en: https://doi.org/10.1002/ohn.70057
15. Flemming S, Hankir M, Ernestus RI, Seyfried F, Germer CT, Meybohm P, et al. Surgery in times of COVID-19—recommendations for hospital and patient management. Langenbecks Arch Surg [Internet]. 2020 [citado el 22 de marzo 2026];405(3):359-64. Disponible en: https://doi.org/10.1007/s00423-020-01888-x
16. Siches I, Vega J, Chomalí M, Yarza B, Estay R, Goyenechea M, et al. El impacto de Covid19 en el sistema de salud y propuestas para la reactivación [Internet]. Santiago: Colegio Médico de Chile; 2020 [citado el 14 de febrero 2024]. Disponible en: https://www.colegiomedico.cl/wp-content/uploads/2020/08/reactivacion-sanitaria.pdf
17. Li J, Jufas N, Forer M, Patel N. Incidence and trends of middle ear cholesteatoma surgery and mastoidectomy in Australia—A national hospital morbidity database analysis. Laryngoscope Investig Otolaryngol [Internet]. 2021 [citado el 22 de marzo 2026];7(1):210-8. Disponible en: https://doi.org/10.1002/lio2.709
18. Chukwueze CM, Okpala OV, Obeagu EI. A systematic review on Methicillin resistant Staphylococcus aureus in patients with surgical wounds. Int J Adv Multidiscip Res [Internet]. 2022 [citado el 22 de marzo 2026];9(9):25-36. Disponible en: https://ijarm.com/pdfcopy/2022/sept2022/ijarm3.pdf
Downloads
Published
Issue
Section
License
Copyright (c) 2026 Revista Confluencia

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.



