Hospital discharge rate for respiratory distress syndrome in newborns between 2021 and 2024 in Chile
DOI:
https://doi.org/10.52611/confluencia.2026.1824Keywords:
Respiratory distress syndrome, Newborn, Infant, Newborn, Hospitalization, ChileAbstract
Introduction: Neonatal respiratory pathology is a leading cause of morbidity, mortality, and admission to neonatal intensive care units both globally and nationally, primarily affecting preterm infants. Objective: To determine the hospital discharge rate for respiratory distress syndrome in newborns in Chile between 2021 and 2024. Methodology: An observational, descriptive, retrospective, and quantitative study was conducted using secondary statistical data from the Department of Health Statistics and Information and the National Institute of Statistics. Central tendency analysis was performed using Excel software. Since the study utilized anonymous public data, ethics committee approval was not required. Result: The highest hospital discharge rate was recorded in 2024, reaching 15,41 per 1.000 live births. Males presented the highest hospital discharge rate during the period (16,92 per 1.000 live births). The longest average length of hospital stay occurred in 2022, with 26,13 days. Discussion: The increase in hospital discharge rate is associated with the rise in prematurity in Chile. The higher incidence in males is linked to hormonal factors influencing surfactant production, while the prolonged stay in 2022 suggests transient logistical challenges in the post-pandemic period. Conclusion: The hospital discharge rate shows an upward trend linked to prematurity in the country. This highlights the need to update national clinical guidelines and review local protocols to effectively address this public health priority.
References
1. Yang Y, Guo C, Zou Y, Shen J, Guo Y, Cheng R, et al. Risk factors for mortality in neonatal ARDS: a multicenter retrospective cohort study in China. Front Med [Internet]. 2025 [citado el 28 de abril 2026];19(6):1049-59. Disponible en: https://doi.org/10.1007/s11684-025-1163-1
2. Mohammadi A, De Luca D, Gauda EB. Characteristics, triggers, treatments, and experimental models of neonatal acute respiratory distress syndrome. Am J Physiol Lung Cell Mol Physiol [Internet]. 2025 [citado el 28 de abril 2026];328(4):L512-L525. Disponible en: https://doi.org/10.1152/ajplung.00312.2024
3. Woldeyes D, Negesse A, Alamneh AA, Jemberie SS, Anteneh AA, Birhanu MY. Incidence and predictors of respiratory distress among neonates admitted to neonatal intensive care unit, Northwest Ethiopia. Sci Rep [Internet]. 2025 [citado el 28 de abril 2026];15(1):30444. Disponible en: https://doi.org/10.1038/s41598-025-05957-3
4. Kumar S, Margekar P, Beck P. Study of Clinico-Etiological Factors of Respiratory Distress in Neonates and Its Immediate Outcome In NICU. Eur J Cardiovasc Med [Internet]. 2025 [citado el 28 de abril 2026];15:224-31. Disponible en: https://doi.org/10.5083/ejcm/25-01-37
5. Huang L, Ye D, Wang J. Analysis of diagnosing neonatal respiratory distress syndrome with lung ultrasound score. Pak J Med Sci [Internet]. 2022 [citado el 28 de abril 2026];38(5):1101-6. Disponible en: https://doi.org/10.12669/pjms.38.5.5202
6. Nova Jarpa G, Gutiérrez Pacheco I, Núñez Arancibia G, Pastorini Peña J, Torruella Peñailillo I, González Schumacher D. Tasa de egreso hospitalario por síndrome de distrés respiratorio del recién nacido durante el año 2020 y 2023 en Chile. Rev Estud Med Sur [Internet]. 2025 [citado el 28 de abril 2026];13(1):42-6. Disponible en: https://doi.org/10.56754/0718-9958.2025.273
7. Cave C, Samano D, Sharma AM, Dickinson J, Salomon J, Mahapatra S. Acute respiratory distress syndrome: A review of ARDS across the life course. J Investig Med [Internet]. 2024 [citado el 28 de abril 2026];72(8):798-818. Disponible en: doi: https://doi.org/10.1177/10815589241270612
8. Silveira Neves G, Silveira Nogueira Reis Z, Maia de Castro Romanelli R, dos Santos Nascimento J, Dias Sanglard A, Batchelor J. The role of chest X-ray in the diagnosis of neonatal respiratory distress syndrome: a systematic review concerning low-resource birth scenarios. Glob Health Action [Internet]. 2024 [citado el 28 de abril 2026];17(1):2338633. Disponible en: https://doi.org/10.1080/16549716.2024.2338633
9. Sweet DG, Carnielli VP, Greisen G, Hallman M, Klebermass-Schrehof K, Ozek E, et al. European Consensus Guidelines on the Management of Respiratory Distress Syndrome: 2022 Update. Neonatology [Internet]. 2023 [citado el 28 de abril 2026];120(1):3-23. Disponible en: https://doi.org/10.1159/000528914
10. Hoshino Y, Arai J, Cho K, Yukitake Y, Kajikawa D, Hinata A, et al. Diagnosis and management of neonatal respiratory distress syndrome in Japan: A national survey. Pediatr Neonatol [Internet]. 2023 [citado el 28 de abril 2026];64(1):61-7. Disponible en: https://doi.org/10.1016/j.pedneo.2022.08.002
11. Richards J, Bell S. A Review of Neonatal Respiratory Distress Syndrome. This life-threatening condition caused by a deficiency of pulmonary surfactant occurs primarily in preterm newborns with underdeveloped lungs [Internet]. USA: US Pharmacist; 2026 [citado el 28 de abril 2026]. Disponible en: https://www.uspharmacist.com/article/a-review-of-neonatal-respiratory-distress-syndrome
12. Carvajal-Encina F, Carvajal Rojas L. Prevención del parto prematuro: Impacto de la Garantía Explícita en Salud. Andes Pediatr [Internet]. 2025 [citado el 28 de abril 2026];96(5):645-53. Disponible en: doi: http://dx.doi.org/10.32641/andespediatr.v96i5.5799
13. Course CW, Bush A, Kotecha S. Looking beyond bronchopulmonary dysplasia: prematurity-associated lung disease and its phenotypes. Lancet Respir Med [Internet]. 2026 [citado el 28 de abril 2026];14(1):60-71. Disponible en: https://doi.org/10.1016/s2213-2600(25)00372-8
14. Fang K, Yue S, Wang S, Wang M, Yu X, Ding Y, et al. The association between sex and neonatal respiratory distress syndrome. BMC Pediatr [Internet]. 2024 [citado el 28 de abril 2026];24(1):129. Disponible en: https://doi.org/10.1186/s12887-024-04596-3
15. Tamayo Pérez VI, Morilla Guzmán AA. Epigenética, sexo masculino y enfermedades neonatales. Rev Cubana Pediatría [Internet]. 2021 [citado el 28 de abril 2026];93(4):e1631. Disponible en: https://revpediatria.sld.cu/index.php/ped/article/view/1631
16. De Luca D, Tingay DG, Van Kaam AH, Courtney SE, Kneyber MCJ, Tissieres P, et al. Epidemiology of Neonatal Acute Respiratory Distress Syndrome: Prospective, Multicenter, International Cohort Study. Pediatr Crit Care Med [Internet]. 2022 [citado el 28 de abril 2026];23(7):524-34. Disponible en: https://doi.org/10.1097/pcc.0000000000002961
17. Instituto Nacional de Estadísticas. Síntesis de Estadísticas Vitales 2022 [Internet]. Santiago (Chile): INE; 2022 [citado el 28 de abril 2026]. Disponible en: https://www.ine.gob.cl/docs/default-source/nacimientos-matrimonios-y-defunciones/publicaciones-y-anuarios/s%C3%ADntesis-anuarios-de-estad%C3%ADsticas-vitales/anuario-de-estad%C3%ADsticas-vitales-2022-s%C3%ADntesis.pdf?sfvrsn=4838c658_6
18. Tana M, Tirone C, Aurilia C, Lio A, Paladini A, Fattore S, et al. Respiratory Management of the Preterm Infant: Supporting Evidence-Based Practice at the Bedside. Children (Basel) [Internet]. 2023 [citado el 28 de abril 2026];10(3):535. Disponible en: https://doi.org/10.3390/children10030535
19. Townsel CD, Emmer SF, Campbell WA, Hussain N. Gender Differences in Respiratory Morbidity and Mortality of Preterm Neonates. Front Pediatr [Internet]. 2017 [citado el 28 de abril 2026];5:6. Disponible en: https://doi.org/10.3389/fped.2017.00006
20. Lingappan K, Alur P, Eichenwald E. The Need to Address Sex as a Biological Variable in Neonatal Clinical Studies. J Pediatr [Internet]. 2023 [citado el 28 de abril 2026];255:17-21. Disponible en: https://doi.org/10.1016/j.jpeds.2022.11.021
Downloads
Published
Issue
Section
License
Copyright (c) 2026 Revista Confluencia

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.



