Global epidemiological overview of cervical cancer from 2002 to 2023
DOI:
https://doi.org/10.52611/confluencia.2025.1465Keywords:
Uterine cervical neoplasms, Cervix uteri, Human papillomavirus virusesAbstract
Introduction: Cervical cancer is the eighth most common cancer worldwide and the second most frequent among women. It is entirely preventable, as its primary cause is infection with the human papillomavirus. Objective: This review aims to analyse the behaviour of cervical cancer internationally, considering its incidence, prevalence, and mortality. Methodology: A descriptive observational study was conducted using secondary data from GLOBOCAN and the Institute for Health Metrics and Evaluation regarding mortality rates, disability-adjusted life years, and hospital discharges. Data from 2002 to 2023 were analyzed. Result: In 2022, cervical cancer was ranked 8th in global incidence, with Latin America and the Caribbean being the region with the highest incidence rate, and 9th in cancers with the highest mortality, with Africa being the region with the highest rate. According to data from 2017-2019, approximately 3,1% of women will be diagnosed with cervical cancer at some point in their lives, with a 5-year relative survival rate of 80,8% between 2014 and 2020. Conclusion: Cervical cancer remains a significant global public health issue despite the availability of effective prevention tools. Unequal access to these strategies perpetuates substantial disparities between regions and population groups, highlighting the need to strengthen equitable access to public health policies.
References
Ministerio de Salud de Chile. Guía de Práctica Clínica sobre el Cáncer de Cuello Uterino [Internet]. Santiago: MINSAL; 2015 [citado el 13 de abril 2024]. Disponible en: https://www.minsal.cl/wp-content/uploads/2015/09/GPC-CaCU.pdf
International Agency for Research on Cancer. World Health Organization. Cancer site ranking - Cervix uteri [Internet]. Ginebra: WHO; 2022 [citado el 13 de abril 2024]. Disponible en: https://gco.iarc.who.int/media/globocan/factsheets/cancers/23-cervix-uteri-fact-sheet.pdf
Singh D, Vignat J, Lorenzoni V, Eslahi M, Ginsburg O, Lauby-Secretan B, et al. Global estimates of incidence and mortality of cervical cancer in 2020: a baseline analysis of the WHO Global Cervical Cancer Elimination Initiative. Lancet Glob Health [Internet]. 2023 [citado el 13 de abril 2024];11(2):e197-e206. Disponible en: https://doi.org/10.1016/s2214-109x(22)00501-0
Monie A, Hung CF, Roden R, Wu TC. Cervarix: a vaccine for the prevention of HPV 16, 18-associated cervical cancer. Biologics [Internet]. 2022 [citado el 7 de julio 2024];2(1):97-105. Disponible en: https://pmc.ncbi.nlm.nih.gov/articles/PMC2727782/
Instituto Nacional del Cáncer. ¿Qué es el cáncer de cuello uterino? [Internet]. USA: NIH; 2023 [citado el 13 de abril 2024]. Disponible en: https://www.cancer.gov/espanol/tipos/cuello-uterino
Government of Canada. Anogenital warts guide: Key information and resources [Internet]. Canada: Public Health Agency of Canada; 2025 [citado el 13 de abril 2024]. Disponible en: https://www.canada.ca/en/public-health/services/infectious-diseases/sexual-health-sexually-transmitted-infections/canadian-guidelines/anogenital-warts.html#t_02
Egawa N. Papillomaviruses and cancer: commonalities and differences in HPV carcinogenesis at different sites of the body. Int J Clin Oncol [Internet]. 2023 [citado el 13 de abril 2024];28(8):956-64. Disponible en: https://doi.org/10.1007/s10147-023-02340-y
Walsh B, O’Neill C. Socioeconomic Disparities Across Ethnicities: An Application to Cervical Cancer Screening. Am J Manag Care [Internet]. 2015 [citado el 20 de junio 2024];21(9):e527-e536. Disponible en: https://www.ajmc.com/view/socioeconomic-disparities-across-ethnicities-an-application-to-cervical-cancer-screening
Ferreccio C. Nuevas estrategias de prevención y control de cáncer de cuello uterino en Chile. Salud Publica Mex [Internet]. 2018 [citado el 20 de junio 2024];60(6):713-21. Disponible en: https://doi.org/10.21149/8577
Urrutia MT, Gajardo M. Adherencia al tamizaje de cáncer cérvicouterino: una mirada desde el modelo de determinantes sociales de la salud. Rev Chil Obstet Ginecol [Internet]. 2015 [citado el 20 de junio 2024];80(2):101-10. Disponible en: https://www.scielo.cl/pdf/rchog/v80n2/art02.pdf
Ibarra-Pérez A. Análisis de la incorporación de la vacuna nonavalente anti-virus papiloma humano en Chile. Mat Actual [Internet]. 2024 [citado el 20 de junio 2024];(1):5. Disponible en: https://doi.org/10.22370/revmat.1.2024.4591
Muslin C. Addressing the burden of cervical cancer for Indigenous women in Latin America and the Caribbean: a call for action. Front Public Health [Internet]. 2024 [citado el 20 de junio 2024];12:1376748. Disponible en: https://doi.org/10.3389/fpubh.2024.1376748
Medina Bueno GA, Ticona Ramos DM, Mares Cuadros CA, Quequezana Guevara RM. The Prevalence of Human Papillomavirus Genotypes in Women with Precancerous Lesions and Cervical Cancer in Arequipa, Peru. Life (Basel) [Internet]. 2025 [citado el 20 de junio 2024];15(2):267. Disponible en: https://doi.org/10.3390/life15020267
Yuan Y, Cai X, Shen F, Ma F. HPV post-infection microenvironment and cervical cancer. Cancer Lett [Internet]. 2021 [citado el 20 de junio 2024];497:243-54. Disponible en: https://doi.org/10.1016/j.canlet.2020.10.034
Roman C, Andrade D, Hernández Y, Salazar ZK, Espinosa L, Campoverde E et al. Biological, demographic, and health factors associated with HPV infection in Ecuadorian women. Front Public Health [Internet]. 2023 [citado el 20 de junio 2024];11:1158270. Disponible en: https://doi.org/10.3389/fpubh.2023.1158270
Hernández-Hernández DM, Apresa-García T, Patlán-Pérez RM. Panorama epidemiológico del cáncer cervicouterino. Rev Med Inst Mex Seguro Soc [Internet]. 2015 [citado el 13 de abril 2024];53(2):S154-S61. Disponible en: https://www.redalyc.org/pdf/4577/457744942006.pdf
Sharipova IP, Musabaev EI, Sadirova SS, Suyarkulova DT, Tashev SE, Akhmedova SK et al. Prevalence of high-risk human papillomavirus genotypes among women in Uzbekistan, 2021-2023. J Gynecol Oncol [Internet]. 2025 [citado el 20 de junio 2025];36(1):e7. Disponible en: https://doi.org/10.3802/jgo.2025.36.e7
Rogua H, Ferrera L, El Mansouri N, Kassidi F, Aksim M, Aghrouch M et al. Human Papillomavirus genotypes distribution and associated risk factors among women living in Southern Morocco. Heliyon [Internet]. 2023 [citado el 20 de junio 2024];9(11):e22497. Disponible en: https://doi.org/10.1016/j.heliyon.2023.e22497
Marks M, Gravitt PE, Gupta SB, Liaw KL, Kim E, Tadesse A, et al. Association of hormonal contraceptive use and human papillomavirus prevalence. Int J Cancer [Internet]. 2011 [citado el 20 de junio 2024];128(12):2962-70. Disponible en: https://doi.org/10.1002/ijc.25628
Wu J, Jin Q, Zhang Y, Ji Y, Li J, Liu X et al. Global burden of cervical cancer: current estimates, temporal trend and future projections based on the GLOBOCAN 2022. J Natl Cancer Cent [Internet]. 2025 [citado el 20 de junio 2024];5(3):322-9. Disponible en: https://doi.org/10.1016/j.jncc.2024.11.006
Vilema-Vizuete EG, Ramos-Sánchez RE, Pozo-Hernández CE, Morillo-Cano JR. Risk factors for HPV infection in university students in Guayaquil. Bol Malariol Salud Ambient [Internet]. 2022 [citado el 20 de junio 2024];62(5):984-9. Disponible en: https://docs.bvsalud.org/biblioref/2023/04/1427024/588-1726-1-pb.pdf
Fernández-Deaza G, Serrano B, Roura E, Castillo JS, Caicedo-Martínez M, Bruni L, et al. Cervical cancer screening coverage in the Americas region: a synthetic analysis. Lancet Reg Health Am [Internet]. 2024 [citado el 20 de junio 2024];30:100689. Disponible en: https://doi.org/10.1016/j.lana.2024.100689
Viveros-Carreño D, Fernandes A, Pareja R. Updates on cervical cancer prevention. Int J Gynecol Cancer [Internet]. 2023 [citado el 20 de junio 2024];33(3):394-402. Disponible en: https://doi.org/10.1136/ijgc-2022-003703
Institute for Health Metrics and Evaluation. GBD results [Internet]. USA: IHME; 2024 [citado el 30 de mayo 2024]. Disponible en: https://vizhub.healthdata.org/gbd-results/
National Cancer Institute. Cancer Stat Facts: Uterine Cancer [Internet]. USA: NIH; 2024 [citado el 18 de abril 2024]. Disponible en: https://seer.cancer.gov/statfacts/html/corp.html
Cohen CM, Wentzensen N, Castle PE, Schiffman M, Zuna R, Arend RC, et al. Racial and Ethnic Disparities in Cervical Cancer Incidence, Survival, and Mortality by Histologic Subtype. J Clin Oncol [Internet]. 2022 [citado el 20 de junio 2024];41(5):1059-68. Disponible en: https://doi.org/10.1200/jco.22.01424
Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin [Internet]. 2018 [citado el 20 de junio 2024];68(6):394-424. Disponible en: https://doi.org/10.3322/caac.21492
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