Hospital discharge rate for sezures in newborns in Chile: An observational study between 2020-2023

Authors

DOI:

https://doi.org/10.52611/confluencia.2025.1414

Keywords:

Chile, Epidemiology, Hospitalization, Neonatology, Seizures

Abstract

Introduction: Neonatal seizures are a medical emergency characterized by episodes of abnormal cerebral electrical activity in the newborn. Objective: Given the age of the data, this study aims to update the hospital discharge rate for neonatal seizures during the period 2020-2023 in Chile. Methodology: Observational, descriptive, and cross-sectional study on the hospital discharge rate due to neonatal seizures in the population under 1 year of age during the period 2020-2023 in Chile, according to the variables of sex and duration of hospital stay. Data were collected from the Department of Health Statistics and Information and the National Institute of Statistics of Chile. Result: A total of 519 cases were studied, determining a hospital discharge rate of 0,60 cases per 1000 inhabitants during this period of time, with the highest rates observed in 2022. A predominance in male sex was noted. The average hospital stay was established at 14,25 days, with longer stays observed in males. Discussion: The obtained hospital discharge rate are similar to those reported internationally, and their trend may be associated with post-COVID consequences. The male predominance aligns with international literature, where it´s associated with greater immaturity and vulnerability at birth. The length of hospital stay appears to be longer than that reported in other countries, which may be explained by substantial differences in the healthcare system. Conclusion: The influence of epidemiological, clinical, and contextual factors on the observed trends is evident, reinforcing the need for a differentiated approach to diagnosis and management.

Downloads

Download data is not yet available.

Author Biographies

Paula Antonia Gutiérrez Ulloa, Estudiante de Medicina, Facultad de Medicina Clínica Alemana de Santiago - Universidad del Desarrollo

Interna de Medicina, Facultad de Medicina Clínica Alemana-Universidad del Desarrollo

Valentina Daniela Benavente Roki, Estudiante de Medicina, Facultad de Ciencias de la Salud - Universidad Autónoma Sede Talca

Interna de Medicina, Universidad autónoma de Chile, Sede Talca

Sofia Inés Gleisner Jerez, Estudiante de Medicina, Facultad de Medicina - Universidad Mayor de Santiago

Interna de Medicina, Facultad de Medicina Universidad Mayor de Santiago

Antonia Muñoz Poblete , Estudiante de Medicina, Facultad de Salud - Universidad de O`Higgins

Medical student, Universidad de O’higgins

Anabel María Cedeño Romero, Médica Cirujana, Universidad de Oriente Venezuela. CESFAM Renca

Médico Cirujano, Universidad de Oriente Venezuela. CESFAM Renca Santiago, Chile

References

Sandoval Karamian A, Pressler R, Hahn C, Hartmann H, Wilmshurst J, Wusthoff C. Neonatal Seizures: Practical Approaches to Classification, Diagnosis and Management. J Int Child Neurol Assoc [Internet]. 2022 [citado el 7 de junio 2025];1(1). Disponible en: https://doi.org/10.17724/jicna.2022.218

Acar DB, Bulbul A, Uslu S. Current overview of neonatal convulsions. SiSli Etfal Hastan Tip Bul [Internet]. 2019 [citado el 28 de mayo 2025];53(1):1-6. Disponible en: https://doi.org/10.14744/semb.2018.22844

Vidaurre J. Convulsiones neonatales: Diagnóstico clínico y electroencefalográfico. Medicina (B. Aires) [Internet]. 2018 [citado el 21 de abril 2025];78(Suppl 2):25-9. Disponible en: https://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0025-76802018000600006&lng=es.

Salazar Cerda CI. Crisis neonatales: Evaluación, diagnóstico y tratamiento. Medicina (B. Aires) [Internet]. 2023 [citado el 28 de mayo 2025];83(Suppl 4):31-9. Disponible en: https://pubmed.ncbi.nlm.nih.gov/37714120/

Shellhaas R, Nordill D, García-Prats J, Dashe J. Características clínicas, evaluación y diagnóstico de las convulsiones neonatales [Internet]. USA: UpToDate: 2025 [citado el 5 de mayo 2025]. Disponible en: https://www.uptodate.com/contents/clinical-features-evaluation-and-diagnosis-of-neonatal-seizures

Ziobro JM, Eschbach K, Shellhaas RA. Novel Therapeutics for Neonatal Seizures. Neurotherapeutics [Internet]. 2021 [citado el 28 de mayo 2025];18(3):1564-81. Disponible en: https://doi.org/10.1007/s13311-021-01085-8

Pressler RM, Abend NS, Auvin S, Boylan G, Brigo F, Cilio MR, et al. Treatment of seizures in the neonate: Guidelines and consensus-based recommendations-Special report from the ILAE Task Force on Neonatal Seizures. Epilepsia [Internet]. 2023 [citado el 28 de mayo 2025];64(10):2550-70. Disponible en: https://doi.org/10.1111/epi.17745

He Y, Tang J, Zhang M, Xiong T, Ojha S, Choonara I, et al. Efficacy of antiepileptic drugs in neonatal seizures: a systematic review protocol. BMJ Paediatr Open [Internet]. 2020 [citado el 28 de mayo 2025];4(1):e000683. Disponible en: https://doi.org/10.1136/bmjpo-2020-000683

Padiyar S, Nusairat L, Kadri A, Abu-Shaweesh J, Aly H. Neonatal seizures in the U.S. National Inpatient Population: Prevalence and outcomes. Pediatr Neonatol [Internet]. 2020 [citado el 28 de mayo 2025];61(3):300-5. Disponible en: https://doi.org/10.1016/j.pedneo.2019.12.006

Spenard S, Ivan Salazar Cerda C, Çizmeci MN. Neonatal Seizures in Low- and Middle-Income Countries: A Review of the Literature and Recommendations for the Management. Turk Arch Pediatr [Internet]. 2024 [citado el 24 de julio 2025];59(1):13-22. Disponible en: https://doi.org/10.5152/turkarchpediatr.2024.23250

Ministerio de Salid de Chile. Guía Clínica AUGE. Epilepsia en Niños. Serie Guías Clínicas [Internet]. Santiago: DIPRECE; 2014 [citado el 28 de mayo 2025]. Disponible en: https://diprece.minsal.cl/wrdprss_minsal/wp-content/uploads/2016/03/GUIA-CLINICA_EPILEPSIA-NI%C3%91OS_web.pdf

Pisani F, Spagnoli C, Falsaperla R, Nagarajan L, Ramantani G. Seizures in the neonate: A review of etiologies and outcomes. Seizure [Internet]. 2021 [citado el 28 de mayo 2025];85:48-56. Disponible en: https://doi.org/10.1016/j.seizure.2020.12.023

Yan K, Cheng G, Zhou W, Xiao F, Zhang C, Wang L, et al. Incidence of Neonatal Seizures in China Based on Electroencephalogram Monitoring in Neonatal Neurocritical Care Units. JAMA Netw Open [Internet]. 2023 [citado el 28 de mayo 2025];6(7):e2326301. Disponible en: https://doi.org/10.1001/jamanetworkopen.2023.26301

Flores Ávila DE, García González MR, Arreaga Sotomayor C, Laime Ramos G, Mejía Castañeda W, Reyna Aguiño H, et al. Factores de riesgo en las convulsiones neonatales estudio a realizar en la unidad de cuidados intensivos neonatales del hospital Francisco Icaza Bustamante, durante el periodo 2018 al 2020. Guayaquil. Ecuador. Ciencia Latina [Internet]. 2022 [citado 28 de mayo 2025];6(2):3716-36. Disponible en: https://doi.org/10.37811/cl_rcm.v6i2.2124

Kelly LA, Branagan A, Semova G, Molloy EJ. Sex differences in neonatal brain injury and inflammation. Front Immunol [Internet]. 2023 [citado 8 de junio 2025];14:1243364. Disponible en: https://doi.org/10.3389/fimmu.2023.1243364

Downloads

Published

2025-08-20

How to Cite

1.
Gutiérrez Ulloa PA, Benavente Roki VD, Gleisner Jerez SI, Muñoz Poblete A, Cedeño Romero AM. Hospital discharge rate for sezures in newborns in Chile: An observational study between 2020-2023. Rev. Conflu [Internet]. 2025 Aug. 20 [cited 2025 Aug. 22];8. Available from: https://revistas.udd.cl/index.php/confluencia/article/view/1414

Issue

Vol. 8 (2025): Revista Confluencia

Section

Investigación Cuantitativa

License

Copyright (c) 2025 Revista Confluencia

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Similar Articles

1 2 3 4 5 6 7 8 9 10 > >> 

You may also start an advanced similarity search for this article.