Mortality from non-traumatic intracerebral hemorrhage as the underlying cause in Chile (2016–2024): descriptive study by sex, age group, and region.
DOI:
https://doi.org/10.52611/confluencia.2026.1659Keywords:
Mortality, Chile, Neurology, Cerebral hemorrhage, EpidemiologyAbstract
Introduction: Non-traumatic intracerebral hemorrhage (ICH) is defined as spontaneous intraparenchymal hemorrhage secondary to underlying small vessel disease. This study aims to establish the mortality rate (MR) of non-traumatic ICH in Chile during the 2016–2024 period. Methods: A descriptive, cross-sectional study was conducted utilizing data from the DEIS (Department of Health Statistics and Information). Variables included sex, age group, ICH subtype, geographical region, and place of death. Ethics committee approval was not required for this study. Results: The overall mortality rate for the period was 8.66 per 100,000 inhabitants. The highest MR was observed in 2016 (9.23 per 100,000 inhabitants). Males exhibited a higher MR (9.28 per 100,000 inhabitants) compared to females. The age group with the highest mortality was individuals over 80 years of age (89.24 per 100,000 inhabitants). Among regions, Ñuble demonstrated the highest MR (11.45 per 100,000 inhabitants). Discussion: The peak MR in 2016 may be attributable to suboptimal management of cardiovascular risk factors (CVRFs). The higher MR in males could be associated with a greater prevalence of diabetes and smoking. The elevated MR in the >80 age group might be attributed to increased frailty, poor treatment adherence, and reduced social support networks. The MR in the Ñuble region is linked to a higher prevalence of CVRFs, specific demographic factors, and limited access to specialized services. Conclusion: ICH represents a significant public health burden in Chile and globally, owing to the high mortality and disability associated with it.
Keywords: Mortality, Chile, Neurology, Cerebral Hemorrhage, Epidemiology.
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Steiner T, Purrucker JC, Aguiar de Sousa D, Apostolaki-Hansson T, Beck J, Christensen H, et al. European Stroke Organisation (ESO) and European Association of Neurosurgical Societies (EANS) guideline on stroke due to spontaneous intracerebral haemorrhage. Eur Stroke J [Internet]. 2025 [citado el 31 de octubre 2025];10(4):1007-86. Disponible en: https://doi.org/10.1177/23969873251340815
GBD 2021 Stroke Risk Factor Collaborators. Global, regional, and national burden of stroke and its risk factors, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021. Lancet Neurol [Internet]. 2024 [citado el 31 de octubre 2025];23(10):973-1003. Disponible en: https://doi.org/10.1016/s1474-4422(24)00369-7
Lavados PM, Hoffmeister L, Moraga AM, Vejar A, Vidal C, Gajardo C, et al. Incidence, risk factors, prognosis, and health-related quality of life after stroke in a low-resource community in Chile (ÑANDU): a prospective population-based study. Lancet Glob Health [Internet]. 2021 [citado el 31 de octubre 2025];9(3):e340-e51. Disponible en: https://doi.org/10.1016/s2214-109x(20)30470-8
Burroughs-Ray DC, VanDillen AF, Jackson CD. Clinical guideline highlights for the hospitalist: 2022 American Heart Association/American Stroke Association Guideline for the management of patients with spontaneous intracerebral hemorrhage. J Hosp Med [Internet]. 2023 [citado el 31 de octubre 2025];18(7):624-6. Disponible en: https://doi.org/10.1002/jhm.13051
Sheth KN. Spontaneous Intracerebral Hemorrhage. N Engl J Med [Internet]. 2022 [citado el 31 de octubre 2025];387(17):1589-96. Disponible en: https://doi.org/10.1056/nejmra2201449
Gross BA, Jankowitz BT, Friedlander RM. Cerebral Intraparenchymal Hemorrhage: A Review. JAMA [Internet]. 2019 [citado el 31 de octubre 2025];321(13):1295-303. Disponible en: https://doi.org/10.1001/jama.2019.2413
Addis A, Baggiani M, Citerio G. Intracranial Pressure Monitoring and Management in Aneurysmal Subarachnoid Hemorrhage. Neurocrit Care [Internet]. 2023 [citado el 31 de octubre 2025];39(1):59-69. Disponible en: https://doi.org/10.1007/s12028-023-01752-y
Amores-Valenciano P, Ruiz Escribano-Taravilla E, Romero-Sánchez CM, Prado-Mira A, García-Gil E, Espejo-López AB, et al. Mortalidad en pacientes con hemorragia intracerebral asociada a anticoagulación oral. Eficacia de un protocolo de reversión y seguimiento clínico (proyecto HIC-ACO). Rev Neurol [Internet]. 2021 [citado el 31 de octubre 2025];73(05):165-73. Disponible en: https://doi.org/10.33588/rn.7305.2020565
Suárez Quesada A, Álvarez Aliaga A, López Espinosa E, Bárzaga Morell S, Santisteban García A. Pronóstico de muerte en pacientes con hemorragia intracerebral supratentorial espontánea. Rev Finlay [Internet]. 2016 [citado el 31 de octubre 2025];6(1):32-40. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S2221-24342016000100005&lng=es
Parry-Jones AR, Krishnamurthi R, Ziai WC, Shoamanesh A, Wu S, Martins SO, et al. World Stroke Organization (WSO): Global intracerebral hemorrhage factsheet 2025. Int J Stroke [Internet]. 2024 [citado el 31 de octubre 2025];20(2):145-50. Disponible en: https://doi.org/10.1177/17474930241307876
Xu L, Wang Z, Wu W, Li M, Li Q. Global, regional, and national burden of intracerebral hemorrhage and its attributable risk factors from 1990 to 2021: results from the 2021 Global Burden of Disease Study. BMC Public Health [Internet]. 2024 [citado el 31 de octubre 2025];24(1):2426. Disponible en: https://doi.org/10.1186/s12889-024-19923-7
Osorio JO, Bedoya Á, Patiño J. Descripción de los pacientes con hemorragia intracerebral espontánea en el Hospital San José de Bogotá. Rev Chil Neurocir [Internet]. 2019 [citado el 31 de octubre 2025];45(2):131-5. Disponible en: https://doi.org/10.36593/rev.chil.neurocir.v45i2.124
Hossin MZ. The male disadvantage in life expectancy: can we close the gender gap? Int Health [Internet]. 2021 [citado el 31 de octubre 2025];13(5):482-4. Disponible en: https://doi.org/10.1093/inthealth/ihaa106
Xiang D, Liu Y, Zhou S, Zhou E, Wang Y. Protective Effects of Estrogen on Cardiovascular Disease Mediated by Oxidative Stress. Oxid Med Cell Longev [Internet]. 2021 [citado el 31 de octubre 2025];2021:5523516. Disponible en: https://doi.org/10.1155/2021/5523516
Nguyen AH, Hurwitz M, Sullivan SA, Saad A, Kennedy JLW, Sharma G. Update on sex specific risk factors in cardiovascular disease. Front Cardiovasc Med [Internet]. 2024 [citado el 31 de octubre 2025];11:1352675. Disponible en: https://doi.org/10.3389/fcvm.2024.1352675
Rajendran A, Minhas AS, Kazzi B, Varma B, Choi E, Thakkar A, et al. Sex-specific differences in cardiovascular risk factors and implications for cardiovascular disease prevention in women. Atherosclerosis [Internet]. 2023 [citado el 31 de octubre 2025];384:117269. Disponible en: https://doi.org/10.1016/j.atherosclerosis.2023.117269
Wang S, Zou XL, Wu LX, Zhou HF, Xiao L, Yao T, et al. Epidemiology of intracerebral hemorrhage: A systematic review and meta-analysis. Front Neurol [Internet]. 2022 [citado el 31 de octubre 2025];13:915813. Disponible en: https://doi.org/10.3389/fneur.2022.915813
Lavados PM, Sacks C, Prina L, Escobar A, Tossi C, Araya F, et al. Incidence, 30-day case-fatality rate, and prognosis of stroke in Iquique, Chile: 2-year community-based prospective study (PISCIS project). Lancet [Internet]. 2005 [citado el 31 de octubre 2025];365(9478):2206-15. Disponible en: https://doi.org/10.1016/s0140-6736(05)66779-7
Lavados PM, Díaz V, Jadue L, Olavarría VV, Cárcamo DA, Delgado I. Socioeconomic and Cardiovascular Variables Explaining Regional Variations in Stroke Mortality in Chile: An Ecological Study. Neuroepidemiology [Internet]. 2011 [citado el 31 de octubre 2025];37(1):45-51. Disponible en: https://doi.org/10.1159/000328872
Seifi A, Rawlings J. Description of intracerebral hemorrhage locations, in the United States, based on international classification of diseases, tenth revision. J Neurol Sci [Internet]. 2022 [citado el 31 de octubre 2025];436:120224. Disponible en: https://doi.org/10.1016/j.jns.2022.120224
Loggini A, Del Brutto VJ, El Ammar F, Bulwa ZB, Saleh Velez F, McKoy C, et al. Intracranial Hemorrhage in Hospitalized Patients: An Infrequently Studied Condition with High Mortality. Neurocrit Care [Internet]. 2020 [citado el 31 de octubre 2025];33(3):725-31. Disponible en: https://doi.org/10.1007/s12028-020-00946-y
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