Narrative review protocol: Quality of life of patients with chronic myeloid leukemia

Abstract

Introduction: Chronic myeloid leukemia is a hematologic malignancy that significantly affects patients’ quality of life. Both disease-related symptoms and adverse effects from treatments such as traditional chemotherapy and tyrosine kinase inhibitors impact physical, emotional, social, and occupational dimensions. Objective: To identify the dimensions of quality of life affected in patients with chronic myeloid leukemia. Methodology: A narrative review of scientific studies indexed in PubMed was conducted, following PRISMA guidelines. The search strategy included the equation: “(chronic myeloid leukemia) AND ((quality of life) OR (wellbeing))”, selecting studies that evaluated quality of life in patients with chronic myeloid leukemia and excluding systematic reviews, meta-analyses, and commentaries. Result: Patients with chronic myeloid leukemia experience physical symptoms such as fatigue, pain, and nausea, mainly associated with tyrosine kinase inhibitors side effects and, to a lesser extent, with chemotherapy, limiting their daily functioning. Psychologically, they suffer from anxiety, depression, and fear of the future, especially when treatment outcomes are uncertain or in case of relapse. Socially, patients report occupational difficulties and family tensions, which negatively influence overall well-being. Conclusion: Chronic myeloid leukemia affects quality of life in a multidimensional way. A comprehensive approach is necessary, addressing treatment-related adverse effects and providing psychological and social support. Strengthening multidisciplinary teams and promoting research are key to improving patient outcomes and overall quality of life.