Children's views on their participation in vaccine clinical trials
DOI:
https://doi.org/10.52611/confluencia.2026.1471Keywords:
Cross-sectional studies, Vaccination, Minors, Bioethics, Health knowledge, Attitudes and PracticeAbstract
Introduction: Since the start of the COVID-19 pandemic, efforts have been made to develop vaccines tailored to the needs of children and adolescents, a group from whom it is important to gather information regarding their participation in clinical trials. Objective: To determine the opinion of children and adolescents aged 7 to 11 and 12 to 17 years regarding their participation in clinical trials for vaccine development, considering the recent inclusion of this demographic in trials in Chile. Methodology: A quantitative descriptive, cross-sectional study using a questionnaire administered to 427 children and adolescents from two schools in the Metropolitan Region. The instrument assessed opinions, concerns, motivations, and willingness to participate in clinical trials. Result: 53,6% of the 7-11 age group and 55,4% of the 12-17 age group agreed with the participation of minors in clinical trials. Additionally, 45% and 42,4%, respectively, indicated their willingness to participate. The primary motivation was the desire to aid in vaccine development, although moderate concerns were evident, particularly regarding potential long-term effects. Discussion: The results reflect a predominantly positive attitude towards pediatric clinical research, with age-group differences in comprehension and argumentation. A clear awareness of justice, altruism, and appreciation for informed consent was observed. Conclusion: Including the voices of children and adolescents in the design of clinical research is essential to ensure respect, understanding, and truly meaningful participation.
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